Endocrine Abstracts

When a craniopharyngioma (CP) causes hypothalamus (HT) damage this will result in hypothalamic obesity (HO), cognitive dysfunction and increased stroke mortality. Suggested treatment when the HT is affected by a CP is subtotal resection and in some cases followed by cranial radiotherapy (CRT). In the preoperative phase, a multidisciplinary team may suggest HT sparing surgery with subtotal tumour removal. If in spite of all efforts the HT is damaged, there will be an immediate ...

Survival rates of childhood cancer have improved markedly and today more than 80% of those diagnosed with a pediatric malignancy will become 5-year survivors. Nevertheless, survivors exposed to cranial radiotherapy (CRT) are at particularly high risk for long-term morbidity, such as endocrine insufficiencies, metabolic complications and cardiovascular morbidity. Deficiencies of one or more anterior pituitary hormones have been described following therapeutic CRT for primary br...

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and accounts for 25% of all childhood cancer. With dramatically improved survival rates the long term treatment complications are very important. ALL patients treated with cranial radiotherapy (CRT) and chemotherapy are at increased risk of GH deficiency (GHD), hyperparathyroidism, thyroid cancer and meningiomas.Method: We present a 45-year-old woman diagnosed with ...

Background: Adult craniopharyngioma (CP) patients without GH therapy exhibit high risk for cardiovascular disease (CVD) and mortality with a higher risk in women than in men. Approximately 50% of children treated for CP are obese at follow-up and hypothalamic damage seems to be a major cause. In GHD CP children GH treatment improves linear growth but does not ameliorate weight gain, but the impact of long-term GH therapy into adulthood is presently unknown.<p class="abstex...

Survivors of childhood (CO) ALL treated with prophylactic cranial radiotherapy (CRT) often exhibit (GHD) and increased cardiovascular risk. The aim of this study was to evaluate the effect of 4 years of GH therapy on cardiovascular risk factors in 16 former ALL patients and to compare them with matched population controls after 4 years.Sixteen former CO ALL patients (women=8), aged 24–37 years, treated with CRT (18–24 Gy) and chemotherapy with ...

Introduction: The demand of cortisol rises during stress and to avoid acute cortisol deficiency, patients undergoing transsphenoidal surgery at Skåne University Hospital (Sweden) receive peri- and postoperative substitution with hydrocortisone (HC), even at normal ACTH function. Some anesthetics are known to affect cortisol levels.This study aimed to assess the perioperative cortisol plasma levels during transsphenoidal surgery in ACTH sufficient an...

Background: Survivors of childhood leukaemia (ALL) treated with cranial radiotherapy (CRT) are at risk for cognitive impairment. Whether the impairment progresses with follow-up time and if survivors with cognitive impairment have an increased risk for overweight, is unknown. We aimed to investigate the long-term cognitive functioning in ALL survivors treated with CRT in comparison to matched controls.Method: Cognitive functioning was investigated in 38 ...

Context: Acute lymphoblastic leukaemia (ALL) is the most common pediatric malignancy and its treatment includes many known risk factors for low bone mineral density (BMD), e.g. glucocorticosteroids, methotrexat and cranial radiotherapy (CRT).Objective: To evaluate bone mineral density (BMD) and markers of bone turn over in a group of adults with childhood onset ALL, treated with CRT and to evaluate the effect of 5 years with, and 8 years without GH thera...

Patients with adult onset GHD (AO-GHD) manifest features of the metabolic syndrome (MetS) (abdominal obesity, dyslipidemia and insulin resistance), a condition associated with increased risk of diabetes mellitus (DM).We assessed metabolic status before and after 2 years of GH treatment and the occurrence of de novo DM in 712 patients with AO-GHD from HypoCCS drawn from the US (32.2%) and Europe (67.8%). Patients were divided into four BMI categori...

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...